Filgrastim (GCSF) is beneficial after autologous peripheral blood grafts with high CD34+ cell content
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چکیده
منابع مشابه
Pegfilgrastim versus filgrastim after high-dose chemotherapy and autologous peripheral blood stem cell support.
BACKGROUND American Society of Clinical Oncology guidelines recommend the use of growth factor after high-dose chemotherapy (HDC) and peripheral blood stem cell (PBSC) support. This randomized trial aims to demonstrate the noninferiority of pegfilgrastim (PEG) compared with filgrastim (FIL) after HDC. PATIENTS AND METHODS Eighty patients were assigned to FIL at a daily dose of 5 mug/kg or a s...
متن کاملHigh CD34(+) cell counts decrease hematologic toxicity of autologous peripheral blood progenitor cell transplantation.
Optimal numbers of CD34(+) cells to be reinfused in patients undergoing peripheral blood progenitor cell (PBPC) transplantation after high-dose chemotherapy are still unknown. Hematologic reconstitution of 168 transplantations performed in patients with lymphoproliferative diseases was analyzed according to the number of CD34(+) cells reinfused. The number of days from PBPC reinfusion until neu...
متن کاملDisseminated toxoplasmosis after CD34+-selected autologous peripheral blood stem cell transplantation.
Haematologica vol. 85(3):March 2000 4. Carlotti A, Chaib F, Couble A, Bourgeois N, Blanchard V, Villard J. Rapid identification and fingerprinting of Candida krusei by PCR-based amplification of the species-specific repetitive polymorphic sequence CKRS-1. J Clin Microbiol 1997; 35:1337-43. 5. Vazquez JA, Beckley A, Donabedian S, Sobel JD, Zervos MJ. Comparison of restriction enzyme analysis ver...
متن کاملIsolation of purified autologous peripheral blood CD34+ cells with low T cell content using CliniMACS device--a local experience.
INTRODUCTION Peripheral blood stem cells (PBSC) mobilised with growth factor with or without chemotherapeutic regimens, are used increasingly in both autologous and allogeneic transplantation. Previously, many PBSC harvests are used directly without ex vivo manipulation, and these PBSC have been shown to be contaminated with tumour cells, which may contribute to subsequent relapses post transpl...
متن کاملRandomized trial of autologous filgrastim-primed bone marrow transplantation versus filgrastim-mobilized peripheral blood stem cell transplantation in lymphoma patients.
Although a large amount of data is available on the effects of filgrastim (granulocyte colony-stimulating factor [G-CSF]) on the mobilization of stem cells in the circulation, data concerning its effects on bone marrow (BM) harvesting is scarce and controversial. We have designed a randomized trial comparing filgrastim-mobilized peripheral blood stem cell (PBSC) transplantation with filgrastim-...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2004
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2003.12.033